Helm Health

vitamins · B12

Vitamin B12

A vitamin essential for nerve function, DNA, and red blood cell formation. Deficiency can cause anemia and nerve symptoms and is more common with age, plant-based diets, and certain medications.

This page is general wellness education, not medical advice. Your own lab’s reference range and your clinician’s interpretation always take precedence.

Typical reference range

GroupGeneral range
Adults~200–900 pg/mL; values 200–300 may be borderline

Optimal-band note: Some practitioners prefer B12 above ~400 pg/mL, since low-normal values can still coincide with deficiency on confirmatory tests (e.g. methylmalonic acid). Soft target only.

Units: pg/mL. Ranges vary by lab and assay — read yours against the range printed on your own report.

What high Vitamin B12 can mean

  • Supplements / injections
  • Liver disease
  • Some blood conditions

What low Vitamin B12 can mean

  • Low intake (vegan/vegetarian)
  • Poor absorption (pernicious anemia, gut conditions)
  • Metformin or acid-reducing drugs
  • Older age

Related markers

Sources